EGFR-IN-68

• Description:

  EGFR-IN-68 (Compound 8d) is a potent EGFR inhibitor with an IC50 of 0.33 μM. EGFR-IN-68 shows anticancer activity[1].

• UNSPSC:

  12352005

• Target:

  EGFR

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/egfr-in-68.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC=C (N2N=C (C3=CC=CC=C3) CC2/C=C/C4=CC=CC=C4) C=C1

• Molecular Formula:

  C24H22N2O

• Molecular Weight:

  354.44

• References & Citations:

  [1]George RF, et al. Some 1,3,5-trisubstituted pyrazoline derivatives targeting breast cancer: Design, synthesis, cytotoxic activity, EGFR inhibition and molecular docking. Bioorg Chem. 2020 Jun;99:103780.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2416925-03-4