MX-68

CAT: 0804-HY-19242Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-19242Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MX-68 is an orally active antifolate agent. MX-68 can prolong the lifespan of MRL/lpr mice, delay the onset of proteinuria, and inhibit the elevation of serum blood urea nitrogen and cholesterol levels. MX-68 is also an anti-rheumatic agent, which exerts potent antiproliferative effects on rheumatoid arthritis-related cells and can inhibit arthritis in rats. MX-68 can be used in the research of autoimmune diseases such as autoimmune kidney disease and rheumatoid arthritis[1][2].
CAS Number
[156579-02-1]
UNSPSC
12352005
Target
Antifolate
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Inflammation/Immunology
Smiles
O=C(O)[C@@H](NC(C1=CC=C2N(CC3=NC4=C(N)N=C(N)N=C4N=C3)CCSC2=C1)=O)CCCC(O)=O
Molecular Formula
C22H24N8O5S
Molecular Weight
512.54
References & Citations
[1]Maruyama N, et al. An improved process for the large-scale preparation of antirheumatic agent MX-68. Organic process research & development, 2004, 8 (6) : 883-888.|[2]Mihara M, et al. A novel antifolate, MX-68, inhibits the development of autoimmune disease in MRL/lpr mice. Int Arch Allergy Immunol. 1997 Aug;113 (4) :454-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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