Anticancer agent 71

• Description :

  Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity[1].

• CAS Number :

  [2453228-45-8]

• UNSPSC :

  12352005

• Target :

  Apoptosis; PARP

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/anticancer-agent-71.html

• Solubility :

  10 mM in DMSO

• Smiles :

  NC1=NC(NC(NC2=CC=C(C(C(F)(F)F)=C2)Cl)=O)=CC(C3=CC=CC=C3)=N1

• Molecular Formula :

  C18H13ClF3N5O

• Molecular Weight :

  407.78

• References & Citations :

  [1]Kilic-Kurt Z, et al. Synthesis and anticancer activity of some pyrimidine derivatives with aryl urea moieties as apoptosis-inducing agents. Bioorg Chem. 2020 Aug;101:104028.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported