Anticancer agent 71

• UNSPSC Description:

  Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity[1].

• Target Antigen:

  Apoptosis; PARP

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/anticancer-agent-71.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=NC(NC(NC2=CC=C(C(C(F)(F)F)=C2)Cl)=O)=CC(C3=CC=CC=C3)=N1

• Molecular Weight:

  407.78

• References & Citations:

  [1]Kilic-Kurt Z, et al. Synthesis and anticancer activity of some pyrimidine derivatives with aryl urea moieties as apoptosis-inducing agents. Bioorg Chem. 2020 Aug;101:104028.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  9007-83-4