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NMDAR/HDAC-IN-1

CAT: 0931-T61451-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T61451-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Others, iGluR, HDAC
Related Pathways
Others, Membrane transporter/Ion channel, Neuroscience, DNA Damage/DNA Repair, Chromatin/Epigenetic
Bioactivity
NMDAR/HDAC-IN-1 (Compound 9d) is a potent dual inhibitor of N-methyl-D-aspartate receptors (NMDARs) and histone deacetylases (HDACs), with a high affinity for NMDARs (Ki = 0.59 μM) and significant inhibitory effects on various HDAC isoforms, including HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC50 values of 2.67 μM, 8.00 μM, 2.21 μM, 0.18 μM, and 0.62 μM, respectively; additionally, it efficiently crosses the blood-brain barrier [1].
Molecular Formula
C22H28N2O3
Molecular Weight
368.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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