MTL-005

CAT: 0804-HY-19938Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-19938Size:1 Each
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Description
MTL-005 is a boron-containing radiosensitizer used in Boron Neutron Capture Therapy (BNCT) . MTL-005 enriches the boron-10 isotope in tumor tissues, causing nuclear fission under thermal neutron irradiation, releasing high linear energy transfer (LET) α particles and lithium ions, which selectively destroy tumor cells while minimizing damage to surrounding normal tissues. MTL-005 significantly controlls the tumor progression in the SCCVII squamous cell carcinoma mouse model and prolonged the survival of the mice. MTL-005 can be used to study solid tumors such as head and neck cancer.
CAS Number
[1030303-53-7]
UNSPSC
12352100
Target
Biochemical Assay Reagents
Related Pathways
Others
Field of Research
Cancer
Smiles
O=N(C1=C2[N-]3C(C=C2)=C(C4=[N]5[Cu+2]3([N]6=C1C=CC6=C7C8=CC(OCC9%10%11%12B%13%14%15([H])B9%16%17([H])B%10%18%19([H])B%11%20%21([H])C%12%13%22([H])B%14%23%24([H])B%15%16%25([H])B%18%17%26([H])B%20%19%27([H])B%21%22%23([H])B%24%25%27%26[H])=CC=C8)[N-]%28C7=CC=C%28C(N(=O)=O)=C5C=C4)C%29=CC=CC(OCC%30%31%32%33B%34%35%36([H])B%30%37%38([H])B%31%39%40([H])B%32%41%42([H])C%33%34%43([H])B%35%44%45([H])B%36%37%46([H])B%39%38%47([H])B%41%40%48([H])B%42%43%44([H])B%45%46%48%47[H])=C%29)=O
Molecular Formula
C38H42B20CuN6O6
Molecular Weight
958.54
References & Citations
[1]Tahara M, et al. Cisplatin/5-FU 100/1000 in Japanese Patients With Recurrent/Metastatic SCCHN: Management of Recurrent Head-and-Neck Squamous Cell Carcinoma. International Journal of Radiation Oncology, Biology, Physics. 2014 Feb 1;88 (2) :509-10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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