RB-005

CAT: 0804-HY-12900Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-12900Size:1 Each
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Description
RB-005 is a selective inhibitor of sphingosine kinase 1 (SK1) (IC50=3.6 µM), with weaker inhibition of another isoenzyme, SK2. The selective inhibition of RB-005 helps to distinguish the biological functions and roles of SK1 and SK2, which can be used in the study of inflammatory diseases and cancer[1].
CAS Number
[1425049-20-2]
UNSPSC
12352005
Target
SphK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rb-005.html
Smiles
CCCCCCCCC1=CC=C(CCN2CCC(O)CC2)C=C1
Molecular Formula
C21H35NO
Molecular Weight
317.51
References & Citations
[1]Baek D J, et al. Structure–activity relationships and molecular modeling of sphingosine kinase inhibitors[J]. Journal of medicinal chemistry, 2013, 56 (22) : 9310-9327.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SphK1

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