HSP90-IN-12

CAT: 0804-HY-147747Size: 1 EachDry Ice: NoHazardous: No

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Description

Among vibsanin a analogues, vibsanin a analog C (VAC) showed anti proliferative effect on various cancer cell lines, and the anti proliferative activity was the strongest among vibsanin a analogues. In addition, VAC fluctuated the amount of hsp90 related proteins in cells and inhibited hsp90 mediated protein refolding of luciferase in vitro.

CAS Number

2408643-60-5

UNSPSC

12352005

Target

HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hsp90-in-12.html

Solubility

10 mM in DMSO

Smiles

C/C(C)=C\CC[C@@]1(/C=C/[C@H]([C@@]2(O[C@@H]2CCC(C(C1)=O)=C)C)OC(/C=C(C)/C)=O)C

Molecular Formula

C25H36O4

Molecular Weight

400.55

References & Citations

[1]Miura K, et al. Identification of vibsanin A analog as a novel HSP90 inhibitor. Bioorg Med Chem. 2020 Jan 15;28 (2) :115253.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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