HSP90-IN-12

HSP90-IN-12

• CAS Number: 2408643-60-5
• UNSPSC Description: Among vibsanin a analogues, vibsanin a analog C (VAC) showed anti proliferative effect on various cancer cell lines, and the anti proliferative activity was the strongest among vibsanin a analogues. In addition, VAC fluctuated the amount of hsp90 related proteins in cells and inhibited hsp90 mediated protein refolding of luciferase in vitro.
• Target Antigen: HSP
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hsp90-in-12.html
• Solubility: 10 mM in DMSO
• Smiles: C/C(C)=C\CC[C@@]1(/C=C/[C@H]([C@@]2(O[C@@H]2CCC(C(C1)=O)=C)C)OC(/C=C(C)/C)=O)C
• Molecular Weight: 400.55
• References & Citations: [1]Miura K,et al. Identification of vibsanin A analog as a novel HSP90 inhibitor. Bioorg Med Chem. 2020 Jan 15;28(2):115253.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported