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HSP90-IN-13

CAT: 0804-HY-146228Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146228Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HSP90-IN-13 (compound 5k) is a highly potent HSP90 pan inhibitor with an IC50 value of 25.07 nM. HSP90-IN-13 has multi-target activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and induces apoptosis of MCF-7 cells through mitochondrial-mediated pathway[1].
CAS Number
2446055-29-2
UNSPSC
12352005
Target
Apoptosis; EGFR; HSP; Topoisomerase; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hsp90-in-13.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC(N2N=NC(CSC3=NC4=C(C(N3CC5=CC=CC=C5)=O)C=C(C)C=C4)=C2)=C1)O
Molecular Formula
C26H21N5O3S
Molecular Weight
483.54
References & Citations
[1]El-Shafey HW, et al. Synthetic approaches, anticancer potential, HSP90 inhibition, multitarget evaluation, molecular modeling and apoptosis mechanistic study of thioquinazolinone skeleton: Promising antibreast cancer agent. Bioorg Chem. 2020 Aug;101:103987.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; HSP90; Topoisomerase; VEGFR2/KDR/Flk-1

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