HSP90-IN-13

HSP90-IN-13

• CAS Number: 2446055-29-2
• UNSPSC Description: HSP90-IN-13 (compound 5k) is a highly potent HSP90 pan inhibitor with an IC50 value of 25.07 nM. HSP90-IN-13 has multi-target activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and induces apoptosis of MCF-7 cells through mitochondrial-mediated pathway[1].
• Target Antigen: Apoptosis; EGFR; HSP; Topoisomerase; VEGFR
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;JAK/STAT Signaling;Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hsp90-in-13.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC=CC(N2N=NC(CSC3=NC4=C(C(N3CC5=CC=CC=C5)=O)C=C(C)C=C4)=C2)=C1)O
• Molecular Weight: 483.54
• References & Citations: [1]El-Shafey HW, et al. Synthetic approaches, anticancer potential, HSP90 inhibition, multitarget evaluation, molecular modeling and apoptosis mechanistic study of thioquinazolinone skeleton: Promising antibreast cancer agent. Bioorg Chem. 2020 Aug;101:103987.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported