γ-Secretase modulator 11

CAT: 0804-HY-147720Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-147720Size:1 Each
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Description
γ-Secretase modulator 11 (1o) showed high potency in vitro and brain exposure, inducing brain a β 42 levels were significantly reduced and showed undetectable inhibition of cytochrome P450 enzymes. In addition, compound 1o showed excellent anti cognitive deficit effect in AD model mice.
CAS Number
[2434630-29-0]
UNSPSC
12352005
Target
γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/γ-secretase-modulator-11.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC=C(C2=C(C)N=C3C(OCC4=CC=C(C5=CC=C(F)C=C5)C=C4F)=CC=CN32)C=C1)NC
Molecular Formula
C28H22F2N4O2
Molecular Weight
484.50
References & Citations
[1]Sekioka R, et al. Optimization and biological evaluation of imidazopyridine derivatives as a novel scaffold for γ-secretase modulators with oral efficacy against cognitive deficits in Alzheimer's disease model mice. Bioorg Med Chem. 2020 Jun 1;28 (11) :115455.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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