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γ-Secretase modulator 12

CAT: 0931-T61881-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T61881-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2204249-82-9
Target
Beta Amyloid, Gamma-secretase, Others
Related Pathways
Others, Proteases/Proteasome, Neuroscience, Stem Cells
Bioactivity
γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM, specifically designed for Alzheimer's disease research. Notably, γ-Secretase modulator 12 exhibits a favorable brain/plasma ratio (Kp, brain = 0.72) in mice [1].
Smiles
CC1=C(N2C(C(OCC3=CC=CC=C3)=CC=C2)=N1)C=4C=C5C(=CC4)C(=O)N(CC)C5
Molecular Formula
C25H23N3O2
Molecular Weight
397.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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