γ-Secretase modulator 11 hydrochloride

• Target:

  Others|||Gamma-secretase

• Related Pathways:

  Neuroscience|||Stem Cells|||Others|||Proteases/Proteasome

• Bioactivity:

  ?-Secretase modulator 11 hydrochloride is a potent, orally active ?-secretase modulator (IC50: 0.029 ?M) . ?-Secretase modulator 11 hydrochloride significantly reduces brain A?42 levels and rescues the cognitive deficits exhibited by AD model mice. ?-Secretase modulator 11 hydrochloride has shown research potential in Alzheimer's disease.

• Smiles:

  Cl.CNC(=O)c1ccc(cn1)-c1c(C)nc2c(OCc3ccc(cc3F)-c3ccc(F)cc3)cccn12

• Molecular Formula:

  C28H23ClF2N4O2

• Molecular Weight:

  520.96

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2434630-30-3