Products for Research Use Only
RegisterLogin

GABAA receptor modulator-2

CAT: 0804-HY-147657Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-147657Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
GABAA receptor modulator-2 (Compound 20) is selective, orally active α5-GABAAR negative allosteric modulator (NAM) with a Ki of 4.1 nM. GABAA receptor modulator-2 shows high-metabolic stability and good CNS safety[1].
CAS Number
2413850-54-9
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gabaa-receptor-modulator-2.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C(C2=CC=C(C=C2)F)=NO1)COC3=NC4=C(C=C3)CN(C(CS(C)(=O)=O)=O)CC4
Molecular Formula
C22H22FN3O5S
Molecular Weight
459.49
References & Citations
[1]Szabó G, et al. Multiparameter Optimization of Naphthyridine Derivatives as Selective α5-GABAA Receptor Negative Allosteric Modulators. J Med Chem. 2022 Jun 9;65 (11) :7876-7895.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-178782GABAA receptor modulator-11
HY-W070739GABAA receptor modulator-12
HY-175670GABAA receptor modulator-10
HY-161784GABAA receptor modulator-5
HY-109572GABAA receptor modulator-1
HY-175251GABAA receptor modulator-9
HY-173616GABAA receptor modulator-8
HY-170903GABAA receptor modulator-3
HY-170902GABAA receptor modulator-4
HY-172588GABAA receptor modulator-7

Alternative Products

CatalogName
T62885-01GABAA receptor modulator-2
T207320-01GABAA receptor modulator-8
T205164-01GABAA receptor modulator-4
T205029-01GABAA receptor modulator-3
GTR19274268-01GABAA receptor modulator-11
GTR19273454-01GABAA receptor modulator-12
T206728-01GABAA receptor modulator-7
GTR19273074-01GABAA receptor modulator-10
GTR19264185-01GABAA receptor modulator-9
GTR19249569-01α5-GABAA receptor modulator 1

Popular Products