GABAA receptor modulator-2

GABAA receptor modulator-2

• CAS Number: 2413850-54-9
• UNSPSC Description: GABAA receptor modulator-2 (Compound 20) is selective, orally active α5-GABAAR negative allosteric modulator (NAM) with a Ki of 4.1 nM. GABAA receptor modulator-2 shows high-metabolic stability and good CNS safety[1].
• Target Antigen: GABA Receptor
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/gabaa-receptor-modulator-2.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=C(C(C2=CC=C(C=C2)F)=NO1)COC3=NC4=C(C=C3)CN(C(CS(C)(=O)=O)=O)CC4
• Molecular Weight: 459.49
• References & Citations: [1]Szabó G, et al. Multiparameter Optimization of Naphthyridine Derivatives as Selective α5-GABAA Receptor Negative Allosteric Modulators. J Med Chem. 2022 Jun 9;65(11):7876-7895.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported