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GABAA receptor modulator-3

CAT: 0804-HY-170903Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170903Size:1 Each
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Description
GABAA receptor modulator-3 (compound 3b) is a positive allosteric modulator (PAM) . GABAA receptor modulator-3 inhibits α1β3γ2 GABAAR at peak and steady state currents with IC50s of 671 and 64 μM, respectively[1].
UNSPSC
12352005
Target
GABA Receptor
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
[H][C@]1(CC[C@@H]2O)[C@]2(C)CC=C(C3=CC=CC(C(C)=O)=C3)C1
Molecular Formula
C18H22O2
Molecular Weight
270.37
References & Citations
[1]Xu Y, et al. Design, Synthesis, and Pharmacological Evaluation of Nonsteroidal Tricyclic Ligands as Modulators of GABAA Receptors. J Med Chem. 2025 Feb 13;68 (3) :3795-3813.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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