Anticancer agent 64

• Description:

  Anticancer agent 64 (compound 5m) shows cytotoxic activity in CCRF-CEM cells, with IC50 of 2.4 μM. Anticancer agent 64 shows good anticancer activity through apoptosis induction. Anticancer agent 64 induces caspase 3 and 7 activation and PARP cleavage. Anticancer agent 64 induces significant effect of mitochondria depolarization[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Bcl-2 Family; Caspase; PARP

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/anticancer-agent-64.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC([C@]12[C@@]([C@@H](CC2)C(C)=C)([H])[C@]3([H])[C@@](CC1)([C@]4([C@]([C@@]5([C@@](C(C)(C6=C(SC(N)=N6)C5)C)([H])CC4)C)([H])CC3)C)C)=O

• Molecular Formula:

  C31H46N2O2S

• Molecular Weight:

  510.77

• References & Citations:

  [1]Borková L, et al. Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid. Eur J Med Chem. 2020 Jan 1;185:111806.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Bax; Bcl-2; Caspase 3; Caspase 7; PARP

• CAS Number:

  2387902-92-1