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Anticancer agent 63

CAT: 0804-HY-147504Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147504Size:1 Each
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Description
Anticancer agent 63 (compound 3h) shows active in reducing the viability of different cancer cell lines, including SW480, HeLa, A549 and MCF-7, with IC50 values at 24 h of 4.9, 11.5, 9.4, and 3.4 μM, respectively. Anticancer agent 63 induce apoptosis in MCF-7 cells via down-regulating the expression of Bcl-2 and up-regulating the expression of IL-2 and Caspase-3. Anticancer agent 63 also shows antioxidant activity[1].
CAS Number
2529657-32-5
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-63.html
Solubility
10 mM in DMSO
Smiles
CC(CC1=CC=C(C=C1)C(C(NCCC[Se]C(F)(F)F)=O)C)C
Molecular Formula
C17H24F3NOSe
Molecular Weight
394.33
References & Citations
[1]He X, et al. Synthesis and biological evaluation of organoselenium (NSAIDs-SeCN and SeCF3) derivatives as potential anticancer agents. Eur J Med Chem. 2020 Dec 15;208:112864.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Caspase 3

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