DTAG-47

CAT: 0804-HY-147098-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-147098-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
DTAG-47 is a FKBP12F36V PROTAC degrader. dTAG-47 efficiently degrades FKBP12F36V-MELK (sg3R) in MELK⁻/⁻ MDA-MB-468-FKBP12F36V-MELK (sg3R) cells. dTAG-47 can be used for the research of basal-like breast cancers (BBC) . (Pink: FKBP12F36V ligand (HY-114420), Blue: CRBN Ligand (HY-W087383), Black: Linker (HY-42773), E3 ligase ligand-linker conjugate (HY-175952) ) [1][2].
CAS Number
[2265886-81-3]
UNSPSC
12352005
Target
FKBP; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dtag-47.html
Purity
99.65
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C2C(NC(CC2)=O)=O)C(C3=CC=C(NCCCCCCCCNC(COC4=C(C=CC=C4)[C@@H](CCC5=CC(OC)=C(C=C5)OC)OC([C@H]6N(CCCC6)C([C@H](C7=CC(OC)=C(C(OC)=C7)OC)CC)=O)=O)=O)C=C31)=O
Molecular Formula
C59H73N5O14
Molecular Weight
1076.24
References & Citations
[1]Hai-Tsang Huang, et al. MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife. 2017 Sep 19;6:e26693.|[2]Sreekanth V, et al. Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes. ACS Cent Sci. 2020 Dec 23;6 (12) :2228-2237.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FKBP12

Related Products

CatalogName
HY-161157-01DTAG-13-NEG
HY-75578-01DTAG Targeting Ligand 1
HY-161157ADTAG-13-NEG (TFA)
HY-114421-01FKBP12 PROTAC dTAG-13
HY-123941-01FKBP12 PROTAC dTAG-7
HY-151443HDAC-IN-47
HY-162545HPK1-IN-47
HY-W762011-01BDE 47
HY-W103964-01HCV-IN-47
HY-178468PARP1-IN-47

Alternative Products

CatalogName
M39438-01DTAG-47
A23960-10DTAG-47 10mg
466260dTAG-47-NEG
A23960-50DTAG-47 50mg
A23960-5DTAG-47 5mg
A23960-100DTAG-47 100mg
6912/5dTAG-7
6605/5dTAG 13
TRC-D710020-2.5MGdTAG-13
MF-0111370-01DTAG-Biotin

Popular Products