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PDHK-IN-5

CAT: 0804-HY-146554Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146554Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDHK-IN-5 (Compound 19) is a potent inhibitor of PDHK with IC50s of 0.006 and 0.0329 μM for PDHK2 and PDHK4, repectively. Pyruvate dehydrogenase kinases (PDHKs) are fascinating agent targets for numerous diseases, including diabetes and cancers. PDHK-IN-5 has the potential for the research of cancer diseases[1].
UNSPSC
12352005
Target
PDHK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pdhk-in-5.html
Solubility
10 mM in DMSO
Smiles
CC1=NC2=C(C3=CC=CC(C4CC4)=C3N2)C=C1C5=NN=C(O5)C(C(C)C)CC(NCC6=CC=CC=C6)=O
Molecular Formula
C30H31N5O2
Molecular Weight
493.60
References & Citations
[1]Bessho Y, et al. Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors. Bioorg Med Chem. 2021 Dec 15;52:116514
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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