PDHK-IN-4

CAT: 0804-HY-146552-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-146552-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
PDHK-IN-4 (Compound 30) is a potent inhibitor of PDHK with IC50s of 0.0051 and 0.0122 μM for PDHK2 and PDHK4, repectively. Pyruvate dehydrogenase kinases (PDHKs) are fascinating agent targets for numerous diseases, including diabetes and cancers. PDHK-IN-4 has the potential for the research of cancer diseases[1].
UNSPSC
12352005
Target
PDHK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pdhk-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C([C@@H]2CN(C3=C4C(NC5=C4C=CC=C5C6CC6)=NC(C)=N3)[C@H](CO)C2)N1)O
Molecular Formula
C24H25N5O3
Molecular Weight
431.49
References & Citations
[1]Bessho Y, et al. Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors. Bioorg Med Chem. 2021 Dec 15;52:116514
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-162586PDHK-IN-7
HY-146801PDHK-IN-3
HY-146554PDHK-IN-5
HY-W099255-01Ethyl 4,4,4,4',4',4'-hexafluoro-DL-valinate
HY-W7200064,4'-Diapo-ω, ω-carotene-4,4'-dial
HY-77910-014- (4-Bromophenyl) -4-hydroxypiperidine
HY-W037331-014,4-Difluorobenzhydrol
HY-W0119184,4'-Dichlorobenzophenone
HY-W2697474,4'-Dimethoxyoctafluorobiphenyl
HY-103610-014,4'-Dimethoxybenzil

Alternative Products

CatalogName
MBS5805095PDHK-IN-4
MF-0141037-01PDHK-IN-5
MF-0148293-01PDHK-IN-7
MBS5803254PDHK-IN-3
MBS9018175Rabbit anti-Caenorhabditis elegans pdhk-2 Polyclonal Antibody
PC52154,4,4,4',4',4'-Hexafluorovaline hydrochloride
PC64124,4,4-Trifluorobutyl 4,4,4-trifluorobutanoate
OR1011275-014,4',4'',4'''-Methanetetrayltetraphenol
OR1011238-014,4,4,4-Silanetetrayltetrabenzaldehyde
OR1011273-014,4',4'',4'''-Methanetetrayltetrabenzaldehyde

Popular Products