KRAS inhibitor-13

KRAS inhibitor-13

• CAS Number: 2230873-96-6
• UNSPSC Description: KRAS inhibitor-13 (compound 5-6) is a potent KRAS G12C inhibitor with an IC50 of 0.883 µM. KRAS inhibitor-13 shows p-ERK inhibition activities with IC50s of 5.9, >100 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-13 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
• Target Antigen: Ras
• Type: Reference compound
• Related Pathways: GPCR/G Protein;MAPK/ERK Pathway
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/kras-inhibitor-13.html
• Solubility: 10 mM in DMSO
• Smiles: C=CC(N1[C@]2([H])[C@@](CC1)([H])N(C3=C4C(C(F)=C(C5=CC(O)=CC6=C5C=CC=C6)C(Cl)=C4)=NS3)C2)=O
• Molecular Weight: 479.95
• References & Citations: [1]Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported