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FGFR4-IN-22

CAT: 0804-HY-170690Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170690Size:1 Each
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Description
FGFR4-IN-22 (compound 10f) is a potent inhibitor of FGFR4, with the IC50 of 5.4 nM. FGFR4-IN-22 serve as a potential lead compound targeting FGFR4 for anti-HCC agent development[1].
CAS Number
2922812-74-4
UNSPSC
12352005
Target
FGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(NC1=CC=CC(C)=C1NC2=NC=C(C=N2)C#CC3=CC=CC(C(NC4=CC=C(CN5CCN(CC5)C)C(C(F)(F)F)=C4)=O)=C3)C=C
Molecular Formula
C36H34F3N7O2
Molecular Weight
653.70
References & Citations
[1]Lei Han, et al. Design, synthesis, and biological evaluation of Ponatinib-based N-Phenylpyrimidine-2-amine derivatives as novel fibroblast growth factor receptor 4 (FGFR4) selective inhibitors. Eur J Med Chem. 2025 Feb 15:284:117206.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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