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Anticancer agent 59

CAT: 0804-HY-146462Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146462Size:1 Each
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Description
Anticancer agent 59 (compound 11) has inhibitory activity against kinds of cancer cell lines, especially in A549 with IC50 of 0.2 μM. Anticancer agent 59 induces apoptosis and an increase of Ca2+ and ROS in cancer cells. Anticancer agent 59 significantly decreases mitochondrial membrane potential. Anticancer agent 59 can suppress tumor growth in A549 mouse xenograft model[1].
CAS Number
2366170-11-6
UNSPSC
12352005
Target
Apoptosis; ROS Kinase
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-59.html
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CC[C@@](C)(C4)C(N[C@H](C(O)=O)CC5=CC=CC=C5)=O)C)=CC([C@]1([H])[C@@]6([C@@](C(C)([C@H](CC6)OC(CC)=O)C)([H])CC2)C)=O)C
Molecular Formula
C42H59NO6
Molecular Weight
673.92
References & Citations
[1]Yin Y, et al. Synthesis and in vitro/in vivo anticancer evaluation of pentacyclic triterpenoid derivatives linked with l-phenylalanine or l-proline [published online ahead of print, 2022 May 11]. Bioorg Chem. 2022;126:105865.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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