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Anticancer agent 57

CAT: 0804-HY-146452Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146452Size:1 Each
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Description
Anticancer agent 57 (compound 14) potently inhibits MDA-MB-231, MDA-MB-468, and MCF-7 cell lines, with IC50s of 6.43 ~ 8.00 μM. Anticancer agent 57 induces cell cycle arrest and significantly promotes apoptosis. Anticancer agent 57 inhibits tumor growth in nude mice xenografted with MADMB-231 cells. Anticancer agent 57 can be used for researching triple negative breast cancer (TNBC) [1].
CAS Number
2408017-71-8
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-57.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC(OC)=C1)/C=C/C2=CC=C(N(CCCl)CCCl)C=C2
Molecular Formula
C20H21Cl2NO2
Molecular Weight
378.29
References & Citations
[1]Elkhalifa D, et al. Design, synthesis, and validation of novel nitrogen-based chalcone analogs against triple negative breast cancer. Eur J Med Chem. 2020;187:111954.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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