NaPi2b-IN-3

• Description :

  NaPi2b-IN-3 (compound 5) is a potent sodium-dependent transport protein 2b (SLC34A2, NaPi2b) inhibitor with IC50s of 71 nM and 28 nM for human NaPi2b and rat NaPi2b, respectively. NaPi2b-IN-3 can be used for researching hyperphosphatemia[1].

• UNSPSC :

  12352005

• Target :

  Sodium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/napi2b-in-3.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCC(N(CC1=CC(C(NC2=C(C3=C(N2)C=CC=C3)C(NC4=CC=C(C=C4)CCCC5=CC=C(C=C5)C(O)=O)=O)=O)=CC=C1)CCN(C(CCC(O)=O)=O)C)CC

• Molecular Formula :

  C45H51N5O7

• Molecular Weight :

  773.92

• References & Citations :

  [1]Ushiki Y, et al. Design, synthesis and biological evaluation of novel indole derivatives as gut-selective NaPi2b inhibitors. Bioorg Med Chem. 2022;66:116783.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2227443-66-3]