NaPi2b-IN-1

• Description :

  NaPi2b-IN-1 is a potent and orally active inhibitor of sodium-dependent phosphate transport protein 2b (NaPi2b) with an IC50 of 64 nM. NaPi2b is primarily expressed in the small intestine, lungs, and testes and plays an important role in phosphate homeostasis. NaPi2b-IN-1 has the potential for the research of hyperphosphatemia[1].

• UNSPSC :

  12352005

• Target :

  Sodium Channel; Sodium Phosphate Cotransporter

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/napi2b-in-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC(F)(F)C(C=C1/C=N/NC(C2=C(NC(C3=CC(COCCOCCOCCOCCOCCOCCN(CC(O)=O)CCOC)=CC=C3)=O)SC4=C2CCC(C)(C)C4)=O)=C(C=C1)Cl

• Molecular Formula :

  C44H58ClF3N4O11S

• Molecular Weight :

  943.46

• References & Citations :

  [1]Maemoto M, et al. Discovery of Gut-Restricted Small-Molecule Inhibitors of Intestinal Sodium-Dependent Phosphate Transport Protein 2b (NaPi2b) for the Treatment of Hyperphosphatemia. J Med Chem. 2022;65 (3) :1946-1960.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1453116-06-7]