NaPi2b-IN-2

• Description :

  NaPi2b-IN-2 (compound 5) is a potent inhibitor of sodium-dependent transport protein 2b (SLC34A2, NaPi2b), with an IC50 of 38 nM for human NaPi2b. NaPi2b-IN-2 can be used for the research of hyperphosphatemia[1].

• UNSPSC :

  12352005

• Target :

  Sodium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/napi2b-in-2.html

• Purity :

  99.02

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(NC1=C(C2=C(S1)CC(C)(CC2)C)C(C3=CN(C4=CC(C(F)(F)F)=C(Cl)C=C4)N=C3)=O)C5=CC(CN(C(CC)CC)CCN(C)C(CCC(O)=O)=O)=CC=C5

• Molecular Formula :

  C41H47ClF3N5O5S

• Molecular Weight :

  814.36

• References & Citations :

  [1]Ushiki Y, et, al. Design, synthesis and biological evaluation of novel 1H-pyrazole-4-carbonyl-4,5,6,7-tetrahydrobenzo [b]thiophene derivatives as gut-selective NaPi2b inhibitors. Bioorg Med Chem Lett. 2022 Mar 1;59:128572.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2227445-31-8]