Antiproliferative agent-5

Antiproliferative agent-5

• CAS Number: 9007-83-4
• UNSPSC Description: Antiproliferative agent-5 (compound 4o) can significantly and irreversibly inhibit proliferation of gastric cancer cells. Antiproliferative agent-5 causes the G2/M phase arrest, and induces ROS accumulation and activation of autophagy. Antiproliferative agent-5 can be used for researching anticancer[1].
• Target Antigen: Autophagy; Reactive Oxygen Species
• Type: Reference compound
• Related Pathways: Autophagy;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/antiproliferative-agent-5.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC=C(NC2=CC(C)=NC3=NC(SCC4=NC5=CC=CC=C5N4)=NN23)C=C1)/C=C/C6=NC(Br)=CC=C6
• Molecular Weight: 597.49
• References & Citations: [1]Wang S, et al. Discovery of new [1,2,4] Triazolo[1,5-a]Pyrimidine derivatives that Kill gastric cancer cells via the mitochondria pathway. Eur J Med Chem. 2020;203:112630.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported