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Antiproliferative agent-5

CAT: 0804-HY-146390Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146390Size:1 Each
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Description
Antiproliferative agent-5 (compound 4o) can significantly and irreversibly inhibit proliferation of gastric cancer cells. Antiproliferative agent-5 causes the G2/M phase arrest, and induces ROS accumulation and activation of autophagy. Antiproliferative agent-5 can be used for researching anticancer[1].
CAS Number
2459892-41-0
UNSPSC
12352005
Target
Autophagy; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antiproliferative-agent-5.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(NC2=CC(C)=NC3=NC(SCC4=NC5=CC=CC=C5N4)=NN23)C=C1)/C=C/C6=NC(Br)=CC=C6
Molecular Formula
C28H21BrN8OS
Molecular Weight
597.49
References & Citations
[1]Wang S, et al. Discovery of new [1,2,4] Triazolo[1,5-a]Pyrimidine derivatives that Kill gastric cancer cells via the mitochondria pathway. Eur J Med Chem. 2020;203:112630.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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