Anticancer agent 50

• Description:

  Anticancer agent 50 (compound 6) is a potent ABCB1 efflux pump modulator. Anticancer agent 50 shows cytotoxic effects and antiproliferative effects. Anticancer agent 50 decreases the expression of cyclin D1 and induces p53 expression. Anticancer agent 50 has the potential for the research of T-lymphoma[1].

• UNSPSC:

  12352005

• Target:

  MDM-2/p53; P-glycoprotein

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/anticancer-agent-50.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC (CN1C (N (C (C2=CC=CC=C2) (C1=O) C3=CC=CC=C3) CCCCCC[Se]C4=CC=CC=C4) =O) =O

• Molecular Formula:

  C30H32N2O4Se

• Molecular Weight:

  563.55

• References & Citations:

  [1]Ali W, et al. Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma. Eur J Med Chem. 2020 Aug 15;200:112435.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2487457-15-6