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ThrRS-IN-3

CAT: 0804-HY-146263Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146263Size:1 Each
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Description
ThrRS-IN-3 (compound 36j) is a highly potent threonyl-tRNA synthetase (ThrRS) inhibitor, with an IC50 value of 19 nM and a Kd of 34 nM for Salmonella enterica ThrRS. ThrRS-IN-3 has antibacterial activities[1].
CAS Number
3031483-23-2
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/thrrs-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(NC[C@@H](C1=CC(C2=CC(CN3)=C(C=C2)C3=O)=CC=C1)NC([C@@H](N)[C@@H](C)O)=O)CCN4C=NC5=C(C4=O)C=C(Cl)C(Cl)=C5
Molecular Formula
C31H30Cl2N6O5
Molecular Weight
637.51
References & Citations
[1]Cai Z, et al. Design, Synthesis, and Proof-of-Concept of Triple-Site Inhibitors against Aminoacyl-tRNA Synthetases. J Med Chem. 2022;65 (7) :5800-5820.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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