Products for Research Use Only
RegisterLogin

ThrRS-IN-1

CAT: 0804-HY-130718Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-130718Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ThrRS-IN-1 (Compound 30d) is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 of 1.4 µM and a Kd of 1.36 µM against Salmonella enterica ThrRS (SeThrRS) . ThrRS-IN-1 simultaneously targets the tRNAThr and L-threonine binding pockets of ThrRS. ThrRS-IN-1 shows potent antibacterial activities[1].
CAS Number
2408626-64-0
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/thrrs-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C/C=C/CNC([C@@H](N)[C@H](O)C)=O)C=NC2=CC(Cl)=C(Cl)C=C21
Molecular Formula
C16H18Cl2N4O3
Molecular Weight
385.25
References & Citations
[1]Junsong Guo, et al. Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping. Eur J Med Chem. 2020 Feb 1;187:111941.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-146263ThrRS-IN-3
HY-139657ThrRS-IN-2
HY-N6838-011,1,1,1-Kestohexaose
HY-157129AMPK-α1β1γ1 activator 1
HY-1336231,1,1-Tribromoacetone
HY-149536TWIK-1/TREK-1-IN-1
HY-W160628S1,1,1-Trimethoxypropane-d5
HY-133630-011-Bromo-1,1-dichloroacetone
HY-W881439-011- (1,1-Dimethylethyl) tridecanedioate
HY-W032015S11-Bromooctane-1,1-d2

Alternative Products

CatalogName
MBS5804390ThrRS-IN-1
T40561ThrRS-IN-2
GTR19212372-01ThrRS-IN-3
E38QA6127ThrRS Antibody
sc-166147ThrRS (A-3)
sc-76658-PRThrRS (h) -PR
CQA6127-01Anti-ThrRS Antibody
sc-76659-PRThrRS (m) -PR
sc-76658ThrRS siRNA (h)
sc-166146ThrRS (C-3)

Popular Products