SFTX-3.3

• Description:

  SFTX-3.3 is a Ca2+ channel antagonist with IC50s of approximately 0.24 mM and 0.70 mM against P-type and N-type channels[1][2].

• UNSPSC:

  12352211

• Target:

  Calcium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/sftx-3-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (NCCCNCCCN) [C@@H] (N) CCCNC (N) =N

• Molecular Formula:

  C12H29N7O

• Molecular Weight:

  287.40

• References & Citations:

  [1]Maria Elisa Calcagnotto, et al. An examination of calcium current function on heterotopic neurons in hippocampal slices from rats exposed to methylazoxymethanol. Epilepsia. 2003 Mar;44 (3) :315-21.|[2]T M Norris, et al. Block of high-threshold calcium channels by the synthetic polyamines sFTX-3.3 and FTX-3.3. Mol Pharmacol. 1996 Oct;50 (4) :939-46.|[3]M Fatehi, et al. Polyamine FTX-3.3 and polyamine amide sFTX-3.3 inhibit presynaptic calcium currents and acetylcholine release at mouse motor nerve terminals. Neuropharmacology. 1997 Feb;36 (2) :185-94.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  N-type calcium channel; P/Q-type calcium channel

• CAS Number:

  141997-14-0