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NVP-CLR457

CAT: 0804-HY-146260Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146260Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NVP-CLR457 (compound 40) is an orally active, potent and balanced pan-class I PI3K inhibitor. NVP-CLR457 shows a clear dose-dependent PK/PD/efficacy relationship. NVP-CLR457 has antitumor activity[1].
CAS Number
1453082-52-4
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nvp-clr457.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(C(F)(F)F)=C(C2=NC(N3CCOCC3)=NC(N4[C@H]([C@H](OC4=O)C)CO)=C2)C=N1
Molecular Formula
C18H20F3N7O4
Molecular Weight
455.39
References & Citations
[1]Fairhurst RA, et al. Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor. J Med Chem. 2022 May 2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

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