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NVP-DFV890

CAT: 0804-HY-155876-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-155876-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NVP-DFV890 (Comopound 102) is a NLRP3 antagonist. NVP-DFV890 can be used for osteoarthritis research[1].
CAS Number
2271394-34-2
Product Name Alternative
NLRP3 antagonist 2
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-antagonist-2.html
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[S@](=N)(C(S1)=CN=C1C(C)(O)C)=O)NC2=C(CCC3)C3=CC4=C2CCC4
Molecular Formula
C19H24N4O3S2
Molecular Weight
420.55
References & Citations
[1]Luigi Franchi, et al. Methods of treating or selecting a treatment for a subject resistant to tnf inhibitor using a nlrp3 antagonist. Patent, WO2020010118A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3

Chemical Information

Nvp-dfv890
CAS Number2271394-34-2
PubChem CID156440583
IUPAC Name1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[[2-(2-hydroxypropan-2-yl)-1,3-thiazol-5-yl]sulfonimidoyl]urea
Molecular FormulaC19H24N4O3S2
Molecular Weight420.6
XLogP4.7
Topological Polar Surface Area152
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count28
Formal Charge0
Complexity704
SMILES
CC(C)(C1=NC=C(S1)S(=N)(=O)NC(=O)NC2=C3CCCC3=CC4=C2CCC4)O
InChI
InChI=1S/C19H24N4O3S2/c1-19(2,25)17-21-10-15(27-17)28(20,26)23-18(24)22-16-13-7-3-5-11(13)9-12-6-4-8-14(12)16/h9-10,25H,3-8H2,1-2H3,(H3,20,22,23,24,26)
InChIKey
LHVWNNYPUDZLSH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Nvp-dfv890
CAS: 2271394-34-2
CID: 156440583
Formula: C19H24N4O3S2
MW: 420.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight420.6
XLogP34.7
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass420.12898299
Monoisotopic Mass420.12898299
Topological Polar Surface Area152 Ų
Heavy Atom Count28
Formal Charge0
Complexity704
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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