NVP-BVU972

• UNSPSC Description:

  NVP-BVU972 is an selective and potent Met inhibitor, with an IC50 of 14 nM. NVP-BVU972 also exhibits good anti-proliferative activity against Met with drug-resistant mutations and inhibits phosphorylation. NVP-BVU972 can be used in study of cancer[1].

• Target Antigen:

  c-Met/HGFR

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/NVP-BVU972.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CN1N=CC(C2=NN3C(C=C2)=NC=C3CC4=CC=C(N=CC=C5)C5=C4)=C1

• Molecular Weight:

  340.38

• References & Citations:

  [1]Tiedt, Ralph, et al. A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients. Cancer Research (2011), 71(15), 5255-5264.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1185763-69-2