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Anticancer agent 65

CAT: 0804-HY-146105Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146105Size:1 Each
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Description
Anticancer agent 65 (compound 4c) shows excellent activity in cancer cell lines, especially A549 cells, with an IC50 of 1.07 μM. Anticancer agent 65 induces S-phase arrest in A549 cells and increases the expression level of p53 and p21. Anticancer agent 65 causes apoptosis, ROS generation and collapse of MMP in A549 cells[1].
CAS Number
2407861-48-5
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; MDM-2/p53; MMP; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-65.html
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@]3([C@@]([C@@H](C[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)OC(C5CCNCC5)=O)C)([H])CC2)C)O)([H])[C@@](CC3)([H])[C@](C)(O)CCCC(C)(O)C)C
Molecular Formula
C36H63NO5
Molecular Weight
589.89
References & Citations
[1]Ma L, et al. Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives. Eur J Med Chem. 2020 Feb 1;187:111964.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; MMP

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