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HSP90-IN-9

CAT: 0804-HY-145814Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145814Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HSP90-IN-9 is a potent and selective HSP90 inhibitor. HSP90-IN-9 displays a fungicidal effect in a dose-dependent manner. HSP90-IN-9 inhibits fungal biofilm formation and fungal morphological changes after being combined with FLC. HSP90-IN-9 recovers FLC resistance by down-regulating the expression of related genes (ERG11, CDR1 and CDR2) [1].
CAS Number
2765247-36-5
UNSPSC
12352005
Target
Fungal; HSP
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hsp90-in-9.html
Solubility
10 mM in DMSO
Smiles
CCNC(C1=NOC(C2=C(C=C(C(C3=CC=C(C=C3)C)=C2)O)O)=C1C4=CC=C(C=C4)CN5CCOCC5)=O
Molecular Formula
C30H31N3O5
Molecular Weight
513.58
References & Citations
[1]Yin W, et al. Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. J Med Chem. 2022, 65 (7) :5539-5564.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90

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