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HSP90-IN-11

CAT: 0804-HY-146325Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146325Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HSP90-IN-11 (Compound 12c) is a potent inhibitor of HSP90. HSP90-IN-11 displays potent HSP90α inhibition comparable to AUY-922 (Luminespib) . HSP90-IN-11 shows significant antiproliferative activity in CRC and NSCLC cells in a double digit nM range. HSP90-IN-11 leads to rapid degradation of client proteins EGFR and Akt in NSCLC cells. HSP90-IN-11 induces significant accumulation of a sub-G1 phase population[1].
CAS Number
2986564-20-7
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hsp90-in-11.html
Solubility
10 mM in DMSO
Smiles
CCN(C1=CC=C(C=C1)CN2C(C(F)=CN(C2=O)C3CCCO3)=O)C(C4=CC(C(C)C)=C(C=C4O)O)=O
Molecular Formula
C27H30FN3O6
Molecular Weight
511.54
References & Citations
[1]Wu WC, et al. Fluoropyrimidin-2,4-dihydroxy-5-isopropylbenzamides as antitumor agents against CRC and NSCLC cancer cells. Eur J Med Chem. 2020 Oct 1;203:112540.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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