Resolvin D5

CAT: 0804-HY-145491-01Size: 5 μg (277.40 μM x 50 μL in Ethanol)Dry Ice: YesHazardous: No
CAT#:0804-HY-145491-01Size:5 μg (277.40 μM x 50 μL in Ethanol)
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Description
Resolvin D5 is a prolytic mediator (SPM) with anti-inflammatory activity derived from oxidized lipids DHA. Resolvin D5 inhibits Th17 cell differentiation and promotes regulatory T cell differentiation, and inhibits CD4+ T cell proliferation. Resolvin D5 attenuates osteoclast differentiation and interferes with osteoclastogenesis. Resolvin D5 also regulates ERK phosphorylation and nuclear translocation of NF-kappaB. Resolvin D5 could be used in rheumatoid arthritis research[1][2].
CAS Number
[578008-43-2]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
ERK; NF-κB
Type
Natural Products
Related Pathways
MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/resolvin-d5.html
Concentration
277.40 μM * 50 μL in Ethanol
Purity
98.3
Solubility
10 mM in DMSO
Smiles
CC/C=C\C[C@H](O)/C=C/C=C\C/C=C\C=C\[C@@H](O)C/C=C\CCC(O)=O
Molecular Formula
C22H32O4
Molecular Weight
360.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Yamada H, et al. Effect of resolvin D5 on T cell differentiation and osteoclastogenesis analyzed by lipid mediator profiling in the experimental arthritis. Sci Rep. 2021 Aug 27;11 (1) :17312.|[2]Chun HW, et al. Resolvin D5, a Lipid Mediator, Inhibits Production of Interleukin-6 and CCL5 Via the ERK-NF-κB Signaling Pathway in Lipopolysaccharide-Stimulated THP-1 Cells. J Microbiol Biotechnol. 2020 Jan 28;30 (1) :85-92.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C
Scientific Category
Natural Products
Clinical Information
No Development Reported

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