Resolvin D5

• Description:

  Resolvin D5 is a prolytic mediator (SPM) with anti-inflammatory activity derived from oxidized lipids DHA. Resolvin D5 inhibits Th17 cell differentiation and promotes regulatory T cell differentiation, and inhibits CD4+ T cell proliferation. Resolvin D5 attenuates osteoclast differentiation and interferes with osteoclastogenesis. Resolvin D5 also regulates ERK phosphorylation and nuclear translocation of NF-kappaB. Resolvin D5 could be used in rheumatoid arthritis research[1][2].

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  ERK; NF-κB

• Type:

  Natural Products

• Related Pathways:

  MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/resolvin-d5.html

• Concentration:

  277.40 μM * 50 μL in Ethanol

• Purity:

  98.3

• Solubility:

  10 mM in DMSO

• Smiles:

  CC/C=C\C[C@H](O)/C=C/C=C\C/C=C\C=C\[C@@H](O)C/C=C\CCC(O)=O

• Molecular Formula:

  C22H32O4

• Molecular Weight:

  360.49

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Yamada H, et al. Effect of resolvin D5 on T cell differentiation and osteoclastogenesis analyzed by lipid mediator profiling in the experimental arthritis. Sci Rep. 2021 Aug 27;11 (1) :17312.|[2]Chun HW, et al. Resolvin D5, a Lipid Mediator, Inhibits Production of Interleukin-6 and CCL5 Via the ERK-NF-κB Signaling Pathway in Lipopolysaccharide-Stimulated THP-1 Cells. J Microbiol Biotechnol. 2020 Jan 28;30 (1) :85-92.

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  -80°C

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [578008-43-2]