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Resolvin D2

CAT: 0804-HY-121636-01Size: 25 μg (265.6 μM x 250 μL in Ethanol)Dry Ice: NoHazardous: No
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CAT#:0804-HY-121636-01Size:25 μg (265.6 μM x 250 μL in Ethanol)
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Description
Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3].
CAS Number
810668-37-2
Product Name Alternative
RvD2
UNSPSC
12352211
Hazard Statement
H225, H319
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/resolvin-d2.html
Concentration
265.6 μM * 500 μL in Ethanol
Purity
99.90
Solubility
10 mM in DMSO
Smiles
CC/C=C\C[C@H](O)[C@H](O)/C=C/C=C/C=C\C=C\[C@@H](O)C/C=C\CCC(O)=O
Molecular Formula
C22H32O5
Molecular Weight
376.49
Precautions
H225, H319
References & Citations
[1]Siddiqui YD, et al. Resolvin D2 Induces Resolution of Periapical Inflammation and Promotes Healing of Periapical Lesions in Rat Periapical Periodontitis. Front Immunol. 2019 Feb 26;10:307.|[2]Spite M, et al. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature. 2009 Oct 29;461 (7268) :1287-91.|[3]Park CK, et al. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.6. J Neurosci. 2011 Dec 14;31 (50) :18433-8.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported