Resolvin D2-d5

CAT: 0804-HY-121636SSize: 10 μg (262.11 μM x 100 μL in Ethanol)Dry Ice: NoHazardous: No
CAT#:0804-HY-121636SSize:10 μg (262.11 μM x 100 μL in Ethanol)
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Description
Resolvin D2-d5 is the deuterium labeled Resolvin D2. Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3].
CAS Number
[1881277-33-3]
Product Name Alternative
RvD2-d5
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
TRP Channel
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Infection; Inflammation/Immunology; Neurological Disease
Concentration
262.11 µM * 100 μL in Ethanol
Purity
99.0
Solubility
10 mM in DMSO
Smiles
[2H]C(C([2H])([2H])[2H])(/C=C\C[C@@H]([C@@H](/C=C/C=C/C=C\C=C\[C@H](C/C=C\CCC(O)=O)O)O)O)[2H]
Molecular Formula
C22H27D5O5
Molecular Weight
381.52
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Siddiqui YD, et al. Resolvin D2 Induces Resolution of Periapical Inflammation and Promotes Healing of Periapical Lesions in Rat Periapical Periodontitis. Front Immunol. 2019 Feb 26;10:307.|[3]Spite M, et al. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature. 2009 Oct 29;461 (7268) :1287-91.|[4]Park CK, et al. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.6. J Neurosci. 2011 Dec 14;31 (50) :18433-8.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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