Clozapine-d4

• Description:

  Clozapine-d4 is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4][5].

• Product Name Alternative:

  HF 1854-d4

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H311, H331, H341, H360, H361

• Target:

  5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; Isotope-Labeled Compounds; mAChR

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling; Others

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Purity:

  99.80

• Solubility:

  10 mM in DMSO|DMF : ≥ 10mg/mL|DMSO : ≥ 10mg/mL|Ethanol : ≥ 5mg/mL

• Smiles:

  CN1CC([2H])([2H])N(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42)C([2H])([2H])C1

• Molecular Formula:

  C18H15D4ClN4

• Molecular Weight:

  330.85

• Precautions:

  H301, H311, H331, H341, H360, H361

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Moreno JL, et al. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl) . 2013 Jan;225 (1) :217-26.|[3]Seeman P, et al. Clozapine, a fast-off-D2 antipsychotic. ACS Chem Neurosci. 2014 Jan 15;5 (1) :24-9.|[4]Zhukovskaya NL, et al. Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. Neurosci Lett. 2000 Jul 21;288 (3) :236-40.|[5]Zorn SH, et al. Clozapine is a potent and selective muscarinic M4 receptor agonist. Eur J Pharmacol. 1994 Nov 15;269 (3) :R1-2.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [204395-52-8]