Clozapine

• Description:

  Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively[1][2][3]. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM) [4].

• Product Name Alternative:

  HF 1854

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H341, H361

• Target:

  5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; mAChR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Clozapine.html

• Concentration:

  10mM

• Purity:

  99.84

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  CN1CCN (CC1) C2=NC3=CC (Cl) =CC=C3NC4=CC=CC=C42

• Molecular Formula:

  C18H19ClN4

• Molecular Weight:

  326.83

• Precautions:

  H301, H341, H361

• References & Citations:

  [1]Seeman P, et al. Clozapine, a fast-off-D2 antipsychotic. ACS Chem Neurosci. 2014 Jan 15;5 (1) :24-9.|[2]Zhukovskaya NL, et al. Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. Neurosci Lett. 2000 Jul 21;288 (3) :236-40.|[3]Moreno JL, et al. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl) . 2013 Jan;225 (1) :217-26.|[4]Zorn SH, et al. Clozapine is a potent and selective muscarinic M4 receptor agonist. Eur J Pharmacol. 1994 Nov 15;269 (3) :R1-2.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  5-HT2 Receptor; D2 Receptor; mAChR1; mAChR4; MUC2; MUC3; α adrenergic receptor; α-1 microglobulin

• CAS Number:

  5786-21-0