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Clozapine

CAT: 0804-HY-14539-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14539-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively[1][2][3]. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM) [4].
CAS Number
5786-21-0
Product Name Alternative
HF 1854
UNSPSC
12352005
Hazard Statement
H301, H341, H361
Target
5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Clozapine.html
Concentration
10mM
Purity
99.84
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CN1CCN(CC1)C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42
Molecular Formula
C18H19ClN4
Molecular Weight
326.83
Precautions
H301, H341, H361
References & Citations
[1]Seeman P, et al. Clozapine, a fast-off-D2 antipsychotic. ACS Chem Neurosci. 2014 Jan 15;5 (1) :24-9.|[2]Zhukovskaya NL, et al. Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. Neurosci Lett. 2000 Jul 21;288 (3) :236-40.|[3]Moreno JL, et al. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl) . 2013 Jan;225 (1) :217-26.|[4]Zorn SH, et al. Clozapine is a potent and selective muscarinic M4 receptor agonist. Eur J Pharmacol. 1994 Nov 15;269 (3) :R1-2.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT2 Receptor; D2 Receptor; mAChR1; mAChR4; MUC2; MUC3; α adrenergic receptor; α-1 microglobulin

Alternative Products

CatalogName
0444/500Clozapine

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