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Clozapine-d8

CAT: 0804-HY-14539S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14539S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Clozapine-d8 is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4].
CAS Number
1185053-50-2
Product Name Alternative
HF 1854-d8
UNSPSC
12352005
Hazard Statement
H301-H341-H361-H362-H372-H411
Target
5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; mAChR
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.68
Solubility
10 mM in DMSO|DMSO : 50mg/mL (ultrasonic)
Smiles
CN1C([2H])([2H])C([2H])([2H])N(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C24)C([2H])([2H])C1([2H])[2H]
Molecular Formula
C18H11D8ClN4
Molecular Weight
334.87
Precautions
P260-P263-P273-P280-P391
References & Citations
[1]Seeman P, et al. Clozapine, a fast-off-D2 antipsychotic. ACS Chem Neurosci. 2014 Jan 15;5 (1) :24-9.|[2]Zhukovskaya NL, et al. Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. Neurosci Lett. 2000 Jul 21;288 (3) :236-40.|[3]Moreno JL, et al. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl) . 2013 Jan;225 (1) :217-26.|[4]Zorn SH, et al. Clozapine is a potent and selective muscarinic M4 receptor agonist. Eur J Pharmacol. 1994 Nov 15;269 (3) :R1-2.|[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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