LRRK2-IN-2

LRRK2-IN-2

• CAS Number: 2641059-19-8
• UNSPSC Description: LRRK2-IN-2 (compoubd 22) is a potent, selective, orally active and brain-penetrant inhibitor LRRK2, with IC50 of [1].
• Target Antigen: LRRK2
• Type: Reference compound
• Related Pathways: Autophagy
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/lrrk2-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: FC1([C@@H](N2C(Cl)=C(C=N2)NC3=NC4=C(C=C(C([C@H]5[C@@H](CN([C@H]6[C@H](COC6)O)CC5)F)=C4)Cl)C=N3)C1)F
• Molecular Weight: 543.37
• References & Citations: [1]Keylor MH, et, al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022 Jan 13;65(1):838-856.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported