RegisterLogin

AL-GDa62

CAT: 804-HY-145269Size: 1 EachDry Ice: NoHazardous: No
1 EachSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
AL-GDa62 is a derivative of the CDH1/E-cadherin modulator SLEC-11 (HY-145268) and induces apoptosis in CDH1-/- cells. AL-GDa62 has an EC50 of 3.2 μM and 2 μM for isogenic mammary epithelial cells MCF10A-WT (wild type) and mutant MCF10A-CDH1-/-, respectively. AL-GDa62 specifically inhibits TCOF1, ARPC5, and UBC9, and suppresses SUMOylation at low micromolar concentrations[1].
CAS Number
[2761538-66-1]
UNSPSC
12352005
Target
Cadherin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/al-gda62.html
Solubility
10 mM in DMSO
Smiles
FC(C=C1)=CC=C1CNC2=CC(C)=NC3=C2C=C(OCCCN4CCCC4)C=C3
Molecular Formula
C24H28FN3O
Molecular Weight
393.50
References & Citations
[1]Andreas Luxenburger, et al. Discovery of AL-GDa62 as a Potential Synthetic Lethal Lead for the Treatment of Gastric Cancer. J Med Chem. 2021 Dec 23;64 (24) :18114-18142.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-125641-01AL-34662
HY-116600AL-4114
HY-114154AL-438
HY-118523AL-321
HY-W743888AL-LAD
HY-146009AL-470
HY-125150AL-3138
HY-108645-01AL 8697
HY-15709-01AL 082D06
HY-167011Al-28

Alternative Products

CatalogName
T61815-01AL-GDa62
MBS5804511AL-GDa62
MBS3614702-01AL 8697
T1070280/DElectrod AL
441095-01AL 8697
T69357-01AL-34662
TCL-00105-01AL-A12
MBS3841322-01AL 8697
T74487-01AL-470
T29812-01AL-272

Popular Products