LY 254155

• Description:

  LY 254155, an antifolate, inhibits hGARFT and binds to mFBP with Kis of 2.1±0.2 and 1.7±0.1 nM, respectively.

• UNSPSC:

  12352005

• Target:

  Antifolate

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/LY_254155.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C2=C(NCC(CCC(S3)=CC=C3C(N[C@@H](CCC(O)=O)C(O)=O)=O)C2)N=C(N)N1

• Molecular Formula:

  C19H23N5O6S

• Molecular Weight:

  449.48

• References & Citations:

  [1]Habeck LL, et al. A novel class of monoglutamated antifolates exhibits tight-binding inhibition of humanglycinamide ribonucleotide formyltransferase and potent activity against solid tumors. Cancer Res. 1994 Feb 15;54 (4) :1021-6.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [135503-67-2]