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LY 254155

CAT: 0804-HY-14523Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14523Size:1 Each
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Description
LY 254155, an antifolate, inhibits hGARFT and binds to mFBP with Kis of 2.1±0.2 and 1.7±0.1 nM, respectively.
CAS Number
135503-67-2
UNSPSC
12352005
Target
Antifolate
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LY_254155.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(NCC(CCC(S3)=CC=C3C(N[C@@H](CCC(O)=O)C(O)=O)=O)C2)N=C(N)N1
Molecular Formula
C19H23N5O6S
Molecular Weight
449.48
References & Citations
[1]Habeck LL, et al. A novel class of monoglutamated antifolates exhibits tight-binding inhibition of humanglycinamide ribonucleotide formyltransferase and potent activity against solid tumors. Cancer Res. 1994 Feb 15;54 (4) :1021-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
T11922-01LY 254155
A21130-50LY 254155 50mg
A21130-25LY 254155 25mg
A21130-5LY 254155 5mg
A21130-100LY 254155 100mg
A21130-10LY 254155 10mg
A21130-1LY 254155 1mg

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