PI3K-IN-29

PI3K-IN-29

• CAS Number: 2768005-77-0
• UNSPSC Description: PI3K-IN-29 is a potent PI3K inhibitor. PI3K-IN-29 displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 μM, respectively. PI3K-IN-29 inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K[1].
• Target Antigen: Akt; PI3K
• Type: Reference compound
• Related Pathways: PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pi3k-in-29.html
• Solubility: 10 mM in DMSO
• Smiles: O=S(NC1=CC(C2=CC=C3N=NC=C(C3=C2)C4=CN=C(N=C4)N5CCOCC5)=CN=C1Cl)(C6=CC=CC=C6)=O
• Molecular Weight: 560.03
• References & Citations: [1]Tian C, et al. Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity. Bioorg Med Chem Lett. 2021, 48:128271.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported