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Trk-IN-11

CAT: 0804-HY-144424Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144424Size:1 Each
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Description
Trk-IN-11 (Compound 14h) is a potent inhibitor of TRK (IC50 = 1.4, 1.8 nM, against TrkA, TrkAG595R, respectively) . As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key agent target in solid tumors. Trk-IN-11 has the potential for the research of cancer disease[1].
CAS Number
2700265-62-7
UNSPSC
12352005
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trk-in-11.html
Solubility
10 mM in DMSO
Smiles
C[C@H]1N2C3=NC4=C(C(NC(C)(COC5=CC(F)=CC=C5C2)C)=O)C=NN4C=C3OC1
Molecular Formula
C21H22FN5O3
Molecular Weight
411.43
References & Citations
[1]Fan Y, et al. Pyrizolo[1,5-a]pyrimidine derivatives of the second-generation TRK inhibitor: Design, synthesis and biological evaluation. Bioorg Med Chem Lett. 2022;63:128646.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrkA

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