Chitin synthase inhibitor 1

Chitin synthase inhibitor 1

• CAS Number: 2763387-69-3
• UNSPSC Description: Chitin synthase inhibitor 1 is a potent and selective chitin synthase (CHS) inhibitor (IC50=0.12 mM). Chitin synthase inhibitor 1 has potent antifungal activity against drug-resistant fungi variants[1].
• Target Antigen: Antibiotic; Fungal
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/chitin-synthase-inhibitor-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NC1=CC=CC=C1Cl)/C=C/C(N2C3(C(NC4=C(C=CC=C4)C3)=O)CCC2)=O
• Molecular Weight: 409.87
• References & Citations: [1]Wu H, et al. Design, synthesis, and biological evaluation of novel spiro[pyrrolidine-2,3'-quinolin]-2'-one derivatives as potential chitin synthase inhibitors and antifungal agents. Eur J Med Chem. 2022, 233:114208.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported