hAChE/Aβ1-42-IN-1

hAChE/Aβ1-42-IN-1

• CAS Number: 2761149-17-9
• UNSPSC Description: hAChE/Aβ1-42-IN-1 (Compound 16) is a potent inhibitor of hAChE and Aβ1-42 aggregation. hAChE/Aβ1-42-IN-1 shows acceptable relative safety upon hepG2 cell line and excellent BBB penetration with wide safety margin. hAChE/Aβ1-42-IN-1 has the potential for the research of Alzheimer disease (AD)[1].
• Target Antigen: Amyloid-β; Cholinesterase (ChE)
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/hache-aβ1-42-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NC1=NNC2=NC=CC=C21)CCN3CCN(CC3)CC4=CC=CC=C4
• Molecular Weight: 364.44
• References & Citations: [1]Waly OM, et al. Synthesis, biological evaluation, and molecular modeling simulations of new heterocyclic hybrids as multi-targeted anti-Alzheimer's agents. Eur J Med Chem. 2022;231:114152.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported