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MPGES1-IN-6

CAT: 0804-HY-144238Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144238Size:1 Each
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Description
MPGES1-IN-6 is a potent inhibitor of mPGES-1 (IC50=0.03 μM), a typical anti-inflammatory drug target.
CAS Number
2914158-00-0
UNSPSC
12352005
Target
PGE synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mpges1-in-6.html
Solubility
10 mM in DMSO
Smiles
S=C1NN=C(O1)C2=CC=C3NC(C4=CC=C(C=C4)OC5=CC=CC=C5)=NC3=C2
Molecular Formula
C21H14N4O2S
Molecular Weight
386.43
References & Citations
[1]Ergül AG, et al. Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase. Eur J Med Chem. 2022 Mar 5;231:114167.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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